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Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study.

TitelInvestigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study.
Publication TypeJournal Article
Year of Publication1997
AuthorsMeulenbelt, I, Bijkerk, C, de Wildt, SC, Miedema, HS, Valkenburg, HA, Breedveld, FC, Pols, HA, Te Koppele, JM, Sloos, VF, Hofman, A, Slagboom, PE, van Duijn, CM
JournalArthritis and rheumatism
Volume40
Issue10
Pagination1760-5
Date Published1997 Oct
ISSN0004-3591
SchlüsselwörterArthrose, Arthrose-Epidemologie
Abstract OBJECTIVE: To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes. METHODS: Cases were selected from a population-based study on the presence of ROA of the knee or hip. Further radiographic analysis included scoring for spine and hand ROA. Controls, selected from the same population, were free of ROA in all joints. RESULTS: The CRTM locus was significantly associated with hip ROA in men (odds ratio 0.50, 95% confidence interval 0.26-0.95). A significant association between ROA and the CRTL1 gene was not observed. CONCLUSION: These results suggest that the CRTM locus may play a role in the sex- and joint site-specific pattern of ROA development.
DOI10.1002/1529-0131(199710)40:10<1760::AID-ART6>3.0.CO;2-W
Alternate JournalArthritis Rheum.
Full Text
PubMed ID9336408
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