|Titel||Plasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Perruccio, AV, Mahomed, NN, Chandran, V, Gandhi, R|
|Journal||The Journal of rheumatology|
|Date Published||2014 Feb|
|Abstract|| OBJECTIVE: To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA).
METHODS: Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses.
RESULTS: Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03).
CONCLUSION: Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA.|
|Alternate Journal||J. Rheumatol.|