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Plasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis.

TitelPlasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis.
Publication TypeJournal Article
Year of Publication2014
AuthorsPerruccio, AV, Mahomed, NN, Chandran, V, Gandhi, R
JournalThe Journal of rheumatology
Volume41
Issue2
Pagination334-7
Date Published2014 Feb
ISSN0315-162X
SchlüsselwörterArthrose, Arthrose-Risiko
Abstract OBJECTIVE: To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA). METHODS: Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses. RESULTS: Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03). CONCLUSION: Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA.
DOI10.3899/jrheum.130709
Alternate JournalJ. Rheumatol.
Full Text
PubMed ID24334649
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